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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM4 All Species: 28.76
Human Site: S6 Identified Species: 45.2
UniProt: P33991 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P33991 NP_005905.2 863 96558 S6 _ _ M S S P A S T P S R R G S
Chimpanzee Pan troglodytes XP_528129 863 96543 S6 _ _ M S S P A S T P S R R G S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535063 929 104136 S72 S A M S S P A S T P S R R G S
Cat Felis silvestris
Mouse Mus musculus P49717 862 96718 S6 _ _ M S S P A S T P S R R S S
Rat Rattus norvegicus NP_387500 862 96552 S6 _ _ M S S P A S T P S R R S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515513 863 97108 S6 _ _ M S S P A S T P S R R R A
Chicken Gallus gallus XP_424376 859 96866 S6 _ _ M S S P A S T P S R R R G
Frog Xenopus laevis P30664 863 97105 S6 _ _ M S S P T S T P S R R R N
Zebra Danio Brachydanio rerio NP_944595 750 84021
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q26454 866 96592 P8 M S S P A R S P S V G G A T P
Honey Bee Apis mellifera XP_624670 636 71159
Nematode Worm Caenorhab. elegans Q21902 759 84917
Sea Urchin Strong. purpuratus XP_801985 910 101460 R48 E H P V T P R R S G R S T A S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315
Baker's Yeast Sacchar. cerevisiae P30665 933 104985 Q57 N N S Q N L S Q G E G N I R A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 87.6 N.A. 94.9 95.1 N.A. 92.4 86.3 85.7 71.3 N.A. 60.1 42.1 28.1 63.3
Protein Similarity: 100 100 N.A. 90 N.A. 97 97.3 N.A. 96.1 93.1 92.9 78.7 N.A. 77.3 54.3 46.9 76.3
P-Site Identity: 100 100 N.A. 86.6 N.A. 92.3 92.3 N.A. 84.6 84.6 76.9 0 N.A. 0 0 0 13.3
P-Site Similarity: 100 100 N.A. 86.6 N.A. 92.3 92.3 N.A. 92.3 84.6 84.6 0 N.A. 20 0 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. 28.9 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. 46.5 62.3 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 7 0 47 0 0 0 0 0 7 7 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 7 7 14 7 0 20 7 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % L
% Met: 7 0 54 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 7 0 0 7 0 0 0 0 0 0 7 0 0 7 % N
% Pro: 0 0 7 7 0 60 0 7 0 54 0 0 0 0 7 % P
% Gln: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 7 7 7 0 0 7 54 54 27 0 % R
% Ser: 7 7 14 54 54 0 14 54 14 0 54 7 0 14 40 % S
% Thr: 0 0 0 0 7 0 7 0 54 0 0 0 7 7 0 % T
% Val: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 47 47 0 0 0 0 0 0 0 0 0 0 0 0 0 % _